What is the prevalence of hypertension in people with HS?

Studies suggest that hypertension is significantly more common in individuals with HS compared to the general population, with prevalence rates ranging from approximately 20% to over 40% in different cohorts. This is notably higher than the general adult population.

Why are HS and hypertension linked?

The link between HS and hypertension is multifactorial, involving chronic inflammation, shared genetic predispositions, metabolic dysfunction, and lifestyle factors. The systemic inflammation characteristic of HS can contribute to endothelial dysfunction and arterial stiffness, key factors in the development of hypertension.

What are the shared risk factors for HS and hypertension?

Shared risk factors include obesity, metabolic syndrome, smoking, and chronic systemic inflammation. These factors can independently or synergistically contribute to the development and worsening of both conditions.

How does managing HS impact hypertension?

Effective management of HS, particularly reducing systemic inflammation, may have a positive impact on blood pressure control. Lifestyle modifications, such as weight management and smoking cessation, are beneficial for both conditions.

What warning signs should I look for regarding hypertension if I have HS?

Hypertension often has no symptoms, which is why it's called the 'silent killer.' Regular blood pressure monitoring is crucial. However, severe hypertension can cause headaches, shortness of breath, or nosebleeds. If you experience these, seek immediate medical attention.

Comorbidity Deep-Dive

Hidradenitis Suppurativa and Hypertension: Understanding the Link

Explore the complex relationship between Hidradenitis Suppurativa (HS) and hypertension, a common comorbidity that requires integrated management strategies.

20-40%

HS patients with Hypertension

~2x Higher

Risk of CVD in HS patients

Chronic

Inflammation Link

Integrated

Management Key

Why are HS and Hypertension often seen together?

The connection between Hidradenitis Suppurativa and hypertension is rooted in shared underlying factors, primarily chronic systemic inflammation. HS is not just a skin condition; it\'s a systemic inflammatory disease. This persistent inflammation can contribute to endothelial dysfunction, arterial stiffness, and metabolic changes that predispose individuals to developing hypertension and other cardiovascular diseases.

The Biological Bridge: How HS Influences Hypertension Risk

Chronic Systemic Inflammation

HS is characterized by persistent inflammation, driven by cytokines like TNF-alpha and IL-17. This systemic inflammation can damage blood vessel linings (endothelium), leading to endothelial dysfunction, a precursor to hypertension and atherosclerosis.

Metabolic Dysfunction

Individuals with HS often have a higher prevalence of metabolic syndrome, obesity, and insulin resistance. These metabolic abnormalities are strong risk factors for hypertension, creating a synergistic effect that elevates cardiovascular risk.

Shared Genetic & Environmental Factors

Emerging research suggests potential shared genetic predispositions and environmental triggers (like smoking) that contribute to both HS and hypertension. Understanding these common pathways can lead to more integrated treatment approaches.

Common Risk Factors: HS and Hypertension

Risk Factor	Impact on HS	Impact on Hypertension	Management Strategy
Obesity	Exacerbates HS severity, increases inflammation.	Major contributor to high blood pressure.	Weight management, healthy diet, exercise.
Smoking	Strongly linked to HS onset and worsening.	Damages blood vessels, increases blood pressure.	Smoking cessation programs.
Chronic Inflammation	Core pathology of HS.	Contributes to endothelial dysfunction, arterial stiffness.	Anti-inflammatory therapies, lifestyle changes.
Insulin Resistance / Metabolic Syndrome	Common comorbidity, influences HS severity.	Directly linked to hypertension development.	Dietary changes, exercise, medication if needed.
Stress	Can trigger HS flares.	Elevates blood pressure, impacts cardiovascular health.	Stress reduction techniques, mindfulness.

Warning Signs & When to Seek Help

Key Warning Signs of Hypertension

Hypertension is often asymptomatic (\'silent killer\'), making regular screening vital.
Severe headaches
Shortness of breath
Nosebleeds
Flushing
Dizziness
Chest pain
Visual changes

If you experience any of these severe symptoms, especially if sudden or persistent, seek immediate medical attention.

Care Coordination is Key

Given the systemic nature of HS and its strong link to hypertension, a coordinated approach to care is essential. Ensure your dermatologist, primary care physician, and any other specialists are aware of all your conditions.

Regular monitoring of blood pressure, cholesterol, and blood sugar levels is crucial for individuals with HS to proactively manage cardiovascular risks.

Frequently Asked Questions

Take Control of Your HS Journey

Understanding comorbidities like hypertension is a crucial step in comprehensive HS management. Connect with resources and support.

References

Almenara-Blasco, M., et al. Multimorbidity of hidradenitis suppurativa: a cross-sectional study. Frontiers in Medicine. 2025;12:1618975. doi:10.3389/fmed.2025.1618975
Kimball, A. B., et al. The Comorbidity Burden of Hidradenitis Suppurativa in the United States. JAMA Dermatology. 2018;154(9):1038-1045. doi:10.1001/jamadermatol.2018.1921
Crowley, J. J., et al. Association of hidradenitis suppurativa disease severity with comorbidities: a retrospective study. British Journal of Dermatology. 2014;171(2):339-347. doi:10.1111/bjd.12986
Midgette, B., et al. Epidemiology of hidradenitis suppurativa and its comorbid conditions: a systematic review. Journal of the American Academy of Dermatology. 2024;S0190-9622(24)02848-2. doi:10.1016/j.jaad.2024.04.017
ACC. When Lesions Go Deep: Hidradenitis Suppurativa and Cardiovascular Risk. American College of Cardiology. 2025 Mar 21. Available from: https://www.acc.org/latest-in-cardiology/articles/2025/03/19/14/24/when-lesions-go-deep
CDC. Hypertension Prevalence Among Adults Aged 18 and Over. NCHS Data Brief No. 364. 2020 Feb. Available from: https://www.cdc.gov/nchs/products/databriefs/db364.htm

Content reviewed for medical accuracy. Always consult a qualified healthcare provider.